Correlation among lipoprotein a and severity and scope of coronary artery lesions in patients with acute myocardial infarction

Wang Hongying; Zhao Hong; Sun Zhanjing; Cui Can; Gu Dingwei

doi:10.3969/j.issn.1674-4055.2019.01.19

Abstract：To investigate the correlation among lipoprotein a [Lp(a)] and severity and scope of coronary artery lesions in patients with acute myocardial infarction (AMI). Methods The patients (n=206, male 132 and female 74) hospitalized due to chest pain and received coronary angiography (CAG) were chosen from Department of Cardiology in Affiliated Hospital of North China University of Science and Technology from July 2017 to Apr. 2018. The clinical data was collected from patients, including age, sex, smoking and drinking history, BMI, hypertension and diabetes history, and levels of plasma Lp(a), TC, TG, HDL-C and LDL-C. The patients were divided, according to definition of myocardial infarction, into angina pectoris group (AP group, n=100) and AMI group (n=106). AMI group was divided, according to CAG results, into 1-vessel lesion group (n=8), 2-vessel lesion group (n=33) and 3-vessel lesion group (n=65). Gensini scores were further calculated based on severity and scope of coronary artery lesions. Results The level of Lp(a) increased in AMI group compared with AP group [(332.67±228.33) mg/L vs. (125.41± 90.76) mg/L, P<0.05]. Gensini scores were higher in patients with Lp(a)＞300 mmol/L than those in patients with Lp(a)<300 mmol/L in AMI group (P<0.01). The results of multi-factor analysis showed that Lp(a) level was correlated to AMI (OR=1.011, P=0.000) after excluded diabetes history, hyperlipidemia and drinking. The level of plasma Lp(a) had no difference among 1-vessel lesion group, 2-vessel lesion group and 3-vessel lesion group. Lp(a) and Gensini scores showed a linear positive correlation (r=0.392, P<0.01). Conclusion The level of plasma Lp(a), hypertension and smoking are risk factors of AMI. Lp(a) is positively correlated to severity of coronary artery lesions and is not correlated to scope of coronary artery lesions of AMI.