Relationship between serum H-FABP and cardiac function in patients with rheumatic heart disease
Zheng Xiong
Zhu Junhui
Wu Yunfeng
Liu Lei
Abstract：To study the relationship between serum heart fatty acid binding protein(H-FABP) and cardiac function in patients with rheumatic heart disease (RHD). Methods 81 RHD patients admitted in Fuyang City People's Hospital from January 2016 to January 2018 were selected as study group, meanwhile another 50 healthy persons with normal cardiac function were selected as control group. The serum level of H-FABP, N-terminal fragment of the prohormone brain-type natriuretic peptide(NT-proBNP), troponin t (cTnT), left ventricular end-diastolic diameter (LVEDD) and left ventricular ejection fraction(LVEF) was compared between the two groups and RHD patients with different NYHA grades, and the correlation between H-FABP and the above indexes was analyzed. Results The level of serum NT-proBNP, H-FABP, cTnT and LVEDD in the study group was significantly higher than those in the control group (P<0.05), but the level of LVEF was lower than that in the control group (P<0.05). The level of serum NT-proBNP, H-FABP, cTnT and LVEDD increased with the increase of cardiac function grading, while LVEF level was opposite, there was a significant difference between the two groups (P<0.05). Serum H-FABP was positively correlated with NT-proBNP, cTnT, LVEDD and NYHY (r=0.721, 0.672, 0.641, 0.714, P<0.05), but negatively correlated with LVEF (r=-0.613, P<0.05). Conclusion The level of serum H-FABP in patients with RHD is abnormally elevated and is negatively correlated with cardiac function. The level of H-FABP can be measured to evaluate the cardiac function of patients with RHD.
Keywords：Heart fatty acid binding proteinRheumatic heart diseaseCardiac functionNT-proBNP
Publication Date：2019-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 44-47 )