Admission hyperglycemia and adverse outcomes in diabetic and non-diabetic patients with non-ST-elevation myocardial infarction undergoing percutaneous coronary intervention
Hao Yuanyuan
Ma Feng
Li Tao
Ma Qiangqiang
Yang Guodong
Hu Peijing
Ma Aiqun
Abstract：Objective This study evaluated the prognostic utility of admission hyperglycemia for 3-year major adverse cardiac events (MACEs) in Non-ST-elevation myocardial infarction (NSTEMI) patients undergoing percutaneous coronary intervention (PCI).Methods This study was a multicenter observation cohort study, and the study had been registered in the Chinese Clinical Trial Register, registration number is ChiCTR-PRN-15007233.Patients with confirmed NSTEMI undergoing percutaneous coronary intervention who were hospitalized between January 2009 and October 2012 were divided into diabetes patients'group and non-diabetes patients'group.According to the blood glucose concentration at admission, patients without diabetes were divided into two groups:admission blood glucose＜144 mg/dl or≥144 mg/dl;patients with diabetes were divided into two groups:admission blood glucose＜180 mg/dl or≥180 mg/dl.All patients were followed up for 3 years after discharge, and the outcomes were assessed.Results In non-diabetic patients, the incidence of major adverse cardiovascular events was higher in the 3 years of admission in the blood glucose≥144 mg/dl group compared with the hospitalized blood glucose＜144mg/dl group, the difference was statistically significant (P＜0.05).Among the patients with diabetes, compared with the group of patients with blood glucose＜180 mg/dL, the incidence of major adverse cardiovascular events in 3 years was higher in the blood glucose≥180 mg/dL group, the difference was statistically significant (P＜0.05).Patients with non-diabetic and admitted to the blood glucose＜144 mg/dl group had the lowest incidence of major adverse cardiovascular events for 3 years, while those with diabetes and admitted to the blood glucose≥180 mg/dl group had the highest 3 years of major adverse cardiovascular events.The rate was statistically significant (P＜0.05).Conclusion Regardless of whether the patient has diabetes or not, admission blood glucose levels can be used as an independent predictor of long-term major adverse cardiovascular events in patients with NSTEMI.
Keywords：Non-ST-elevation myocardial infarctionAdmission plasma glucoseMajor adverse cardiac eventsMortality
Publication Date：2018-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 1560-1564 )