The risk prediction value of combining the level of lipoprotein-associated phospholipase A2 and antithrombin Ⅲ for non-ST-segment elevation acute coronary syndrome
Lu Jinyang
Zheng Di
Zhang Quan
Li Wenhua
Abstract：Objective To investigate the change and risk prediction value of lipoprotein-associated phospholipase A2(Lp-PLA2) and antithrombinⅢ (AT-Ⅲ) in patients with non-ST-segment elevation acute coronary syndrome (NSTE-ACS), and the combination of Global Registry of Acute Coronary Events (GRACE) score to observe the value of coronary heart disease risk stratification.Methods A total of 249 patients admitted in our hospital were enrolled.The patients were divided into two groups:NSTE-ACS group (183 cases) and Control group (66 cases).The differences between the two groups of Lp-PLA2 and AT-Ⅲwere compared, and the GRACE scoring system was used for scoring and stratification.The Gensini score system was used to assess the degree of coronary artery stenosis.Results Lp-PLA2 level in the NSTE-ACS group was significantly higher than that in the Control group (P＜0.05), but AT-Ⅲlevel was lower than that in the Control group (P＜0.05).In the groups of different Gensini score, the level of Lp-PLA2 increased in each subgroup (P＜0.05).Compared with the low-risk subgroup and the middle-risk subgroup, the AT-III activity was lower and the Gensini score was higher in the highrisk subgroup (P＜0.05).Logistic regression analysis showed that Lp-PLA2 and GRACE scores were independent risk factors for NSTE-ACS, and AT-Ⅲwas a protective factor for NSTE-ACS.Correlation analysis showed that Lp-PLA2 was positively correlated with Gensini score and GRACE score, and AT-Ⅲwas significantly negatively correlated with Gensini score and GRACE score.Conclusion The level of Lp-PLA2 and AT-Ⅲhave certain risk predictive value in NSTE-ACS patients.
Keywords：Non-ST-segment elevation acute coronary syndromeLipoprotein-associated phospholipase A2Antithrombin ⅢGensini scoresGRACE score
Publication Date：2018-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 1553-1556 )