Relationship among serum Lp-PLA2, suPAR, MIF and coronary artery lesions in patients with coronary heart disease
Xie Chun
Qi Jian
Wei Chunyan
Abstract：Objective To investigate the changes of serum lipoprotein-associated phospholipase A2(LpPLA2), soluble urokinase-type plasminogen activator receptor (suPAR) and macrophage migration inhibitory factor (MIF) and relationship between them and coronary artery lesions in patients with coronary heart disease (CHD).Methods CHD patients (n=160, CHD group) diagnosed by coronary angiography (CAG) were chosen from Department of Cardiology in People's Hospital of Laiwu City from Jan.2015 to Dec.2016, and normal controls (n=80, control group) were chosen at the same time.The levels of serum LP-PLA2, suPAR and MIF were detected in 2 groups.CHD group was divided, according to lesion vessels, into subgroups.Results The levels of serum LP-PLA2, suPAR and MIF were significantly higher in CHD group than those in control group (P＜0.05).The levels of serum LP-PLA2, suPAR and MIF had significant ascending trends in different subgroups, and they were higher3-vessel lesion subgroup than those in 1-vessel lesion subgroup and 2-vessel lesion subgroup (P＜0.05), and were higher in 2-vessel lesion subgroup than those in 1-vessel lesion subgroup (P＜0.05).The levels of serum LP-PLA2, suPAR and MIF were positively correlated to Gensini scores (r=0.617, r=0.628, r=0.661, all P＜0.05).Conclusion The levels of serum LP-PLA2, suPAR and MIF increase significantly in CHD patients compared with normal population, and they were positively correlated to severity of coronary artery stenosis.
Keywords：Coronary heart diseaseLipoprotein-associated phospholipase A2Soluble urokinase-type plasminogen activator receptorMacrophage migration inhibitory factor
Publication Date：2018-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 1550-1552 )