Influence of levocarnitine on heart function, ventricular remodeling and quality of life in patients with chronic congestive heart failure
Zhang Xiaohui
Chang Guodong
Abstract：Objective To observe the influence of levocarnitine on heart function, ventricular remodeling and quality of life (QOL) in patients with chronic congestive heart failure (CCHF).Methods CCHF patients (n=120) were randomly divided into control group and observation group (each n=60), and control group was given routine therapy and observation group was additionally given levocarnitine for 8 weeks as one therapeutic course.The clinical efficacy, heart function, 6-minute walk distance (6MWD), and serum NT-proBNP, hs-cTnT and matrix metalloproteinase (MMP) were compared between 2 groups.QOL was reviewed by using Minnesota Living with Heart Failure Questionnaire (MLHFQ), and adverse reactions were recorded.Results The total clinical efficacy was 91.7％in observation group, which was significantly higher than that in control group (71.7％, P＜0.05).After treatment, LVEF, NT-proBNP, hs-cTnT, 6MWD, MMP-2, MMP-9 and scores of physical dimensions and the total score of MLHFQ were all significantly superior in observation group to those in control group (all P＜0.05).There were no evident adverse reactions observed in 2 groups.Conclusion Levocarnitine is safe and effective in treatment of CCHF, which is worth clinical promoting.
Keywords：LevocarnitineChronic congestive heart failureClinical efficacyQuality of lifeHeart functionVentricular remodeling
Publication Date：2018-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 1547-1549,1552 )