Curative effect of immunoglobulin combined with levosimendan on senile dilated cardiomyopathy and its influence on serum soluble Sema4D and sTWEAK
Lin Zhaoheng
Wu Jiaqi
Feng Manzhi
Abstract：Objective To investigate the curative effect of immunoglobulin combined with levosimendan on senile dilated cardiomyopathy (DCM) and its influence on serum soluble Sema4D (sSema4D) and sTWEAK.Methods The elderly DCM patients (n=90) were chosen from People's Hospital of Xishuangbanna Dai Autonomous Prefecture from Apr.2016 to Apr.2018, and then divided randomly into observation group (n=50) and control group (n=40).On the base of routine treatment, control group was given levosimendan and observation group was given immunoglobulin combined with levosimendan for 4 weeks continuously.The clinical efficacy, heart function, changes of serum sSema4D and sTWEAK and adverse reactions were compared between 2 groups.Results The total effective rate was significantly higher in observation group than that in control group[94.00％ (47/50) vs.77.50％ (31/40), P＜0.05].LVEF was significantly higher, LVEDD and LVESD significantly lower in observation group than those in control group (P＜0.05).The expressions of sSema4D and sTWEAK were significantly lower in observation group than those in control group (P＜0.05).The difference in adverse reactions during treatment had no statistical significance between 2 groups (P＞0.05).Conclusion Immunoglobulin combined with levosimendan can effectively improve heart function in elderly DCM patients, and the internal mechanism may be related to reducing expressions of sSema4D and sTWEAK and reversing left ventricular remodeling.
Keywords：Dilated cardiomyopathyAgednessLevosimendanImmunoglobulinSoluble Sema4DSoluble tumor necrosis factor-like weak apoptosis inducing factor
Publication Date：2018-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 1544-1546 )