Correlation among placental growth factor, soluble tyrosine kinase receptor-2 and quantitative angiography features of target vessels in patients with coronary borderline lesions
Su Xiaoli
Wang Xuanqi
Wu Xiaopeng
Zhang Yan
Wang Yan
Abstract：Objective To analyze the correlation placental growth factor (PLGF), soluble tyrosine kinase receptor-2(sTie-2) and quantitative angiography features of target vessels in patients with coronary borderline lesions.Methods The clinical data of patients with coronary borderline lesions (n=183) diagnosed by coronary angiography were analyzed in Department of Cardiovascular Medicine in Fourth People's Hospital of Shaanxi Province from Jan.2016 to Jan.2018.All patients were divided, according to different coronary plaque morphology, into coronary atherosclerosis group (AS group, n=57), unstable angina pectoris group (UAP group, n=71) and stable angina pectoris group (SAP group, n=55).The results of coronary angiography were analyzed, and levels of plasma PLGF and sTie-2 were detected.The levels of PLGF and sTie-2, quantitative angiography features of target vessels, lesion extent and morphology and vulnerable lesions were compared among 3 groups.The correlation among PLGF, sTie-2 and quantitative angiography features of target vessels were analyzed by using Pearson correlation analysis.Results PLGF level was significantly higher in UAP group than that in SAP group and AS group (P＜0.05), and difference in PLGF level had no statistical significance between SAP group and AS group (P＞0.05).The level of sTie-2 was significantly higher in UAP group than that in AS group (P＜0.05), and difference in sTie-2 level had no statistical significance between UAP group and SAP, and between SAP group and AS (P＞0.05).The difference in the minimal lumen diameter (MLD), diameter stenosis rate, minimal lumen area (MLA) and area stenosis rate had statistical significance among SAP group, UAP group and AS group (P＜0.05), and the difference had no statistical significance between UAP group and AS group (P＞0.05).The plaque area was significantly larger in UAP group than that in AS group (P＜0.05), and difference in plaque area had no between UAP group and SAP group, and between SAP group and AS group (P＞0.05).The comparison in constituent ratio of target vessel local lesions, eccentric lesion, smooth lesion and vulnerable lesions of target vessels showed that the difference had statistical significance among 3 groups (P＜0.05).Pearson correlation analysis showed that PLGF was positively correlated to MLA (P＜0.05), and sTie-2 was positively correlated to MLA and MLD (P＜0.05).Conclusion The levels of PLGF and sTie-2 increase, take part in angiogenesis in plaques and are closely correlated to quantitative angiography features of target vessels, which are expected to be the indexes for predicting plaque vulnerability.
Keywords：Coronary borderline lesionsPlacental growth factorSoluble tyrosine kinase receptor-2Quantitative angiographyPlaque vulnerability
Publication Date：2018-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 1540-1543 )