Application of serum cardiac troponin Ⅰ, plasma brain natriuretic peptide and level of in-hospital systolic blood pressure in treatment of patients with acute heart failure
Luo Weigang
Guo Liang
Abstract：Objective To discuss the difference in serum cardiac troponin (cTnI), plasma brain natriuretic peptide (BNP) and level of admission systolic blood pressure (SBP) in patients with acute heart failure (AHF).Methods AHF patients (n=116) were chosen into study group from Central Hospital of Baoji City from Mar.2015 to Mar.2017, and at the same time other patients with matched age and sex and without history of heart disease (n=116) were chosen into control group.The study groups was further divided into positive cTnI group (cTnI＞0.04 ng/ml), negative cTnI group (cTnI≤0.04 ng/ml), positive BNP group (BNP＞300 pg/ml) and negative BNP group (BNP≤300 pg/ml).All indexes were compared and analyzed in all groups at time of admission and hospitalization and after discharge from hospital.Results The level of cTnI (0.5231±1.0513) ng/ml and BNP level (1162.8±820.8) pg/ml were higher in study group than those in control group[ (0.0315±0.0163) ng/ml, (112.3±75.7) pg/ml, P＜0.05]at admission time.The level of LVEF (36.81±3.39) ％was lower in positive cTnI group than that in negative cTnI group (41.86±3.46) ％, and in-hospital death rate and discharge recurrent rate were higher in positive cTnI group than those in negative cTnI group (P＜0.05).The level of LVEF (35.97±3.51) ％was lower in positive BNP group (41.36±3.52) ％than that in negative BNP group (41.36±3.52) ％, and in-hospital death rate and discharge recurrent rate were higher in positive BNP group than those in negative BNP group (P＜0.05).As the increase of admission SBP, LVEF level increased significantly, and in-hospital death rate and discharge recurrent rate decreased significantly in AHF patients (P＜0.05).The levels of serum cTnI and plasma BNP decreased sharply in positive cTnI group and positive BNP group after patients'symptoms stabilized (P＜0.05).Conclusion The level of serum cTnI can well reflect myocardial injury conditions, and level of plasma BNP can well reflect the impairment of left ventricular load in AHF patients.The level of admission SBP can reflect cardiac decompensation and ejection ability in AHF patients.The active monitoring on these 3 indexes has great significance to right judgment in patients'conditions in clinical treatment.
Keywords：Acute heart failureBrain natriuretic peptideSerum cardiac troponinCardiac decompensation
Publication Date：2018-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 1516-1519 )