Relationship among monomers C-reactive protein, global area strain and severity of coronary artery lesions in patients with ST-segment elevation myocardial infarction
Yuan Yi
Liu Junxiang
Wu Yan
Zhang Yanyue
Abstract：Objective To analyze the relationship among monomers C-reactive protein (mCRP), global area strain (GAS) and severity of coronary artery lesions in patients with ST-segment elevation myocardial infarction (STEMI).Methods STEMI patients (n=124) were chosen from Affiliated Hospital of Logistics University of People's Armed Police Force from Jan.2014 to June 2017.The patients were divided, according to Gensini integrals, into mild lesion group (0＜Gensini integrals≤40, n=32), moderate lesion group (40＜Gensini integrals＜80, n=55 and severe lesion group (Gensini integrals≥80, n=37), and other cases with normal results of coronary angiography were chosen into control group (n=30).The general clinical data, mCRP and GAS were compared in all groups, and relationship among mCRP, GAS and severity of coronary artery lesions was analyzed by using Pearson correlation analysis.Results The difference in sex and average age had no statistical significance among all groups (P＞0.05).The levels of TC, TG and LDL-C were significantly higher, and level of HDL-C was significantly lower in mild lesion group, moderate lesion group and severe lesion group than those in control group (P＜0.05).The levels of mCRP and LVEF were significantly higher, and level of GAS was significantly lower in mild lesion group, moderate lesion group and severe lesion group than those in control group (P＜0.05).The level of mCRP increased and level of GAS decreased as severity of coronary artery lesions increased, and difference in levels of mCRP and GAS had statistical significance among mild lesion group, moderate lesion group and severe lesion group (P＜0.05).The results of Pearson correlation analysis showed that mCRP level was positively correlated to Gensini integrals (r=0.672, P＜0.05), and GAS level was negatively correlated to Gensini integrals (r=-0.562, P＜0.05).Conclusion The levels of mCRP and GAS are closely correlated to severity of coronary artery lesions, so they can be used to review the severity of coronary artery lesions in patients with STEMI.
Keywords：Acute ST-segment elevation myocardial infarctionCoronary artery lesionsGensini integrals
Publication Date：2018-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 1513-1515,1519 )