Correlation among serum low-density lipoprotein-cholesterol, Annexin A1 and severity of coronary artery stenosis in patients with coronary heart disease
Liang Wenhui
Zhu Yuchun
Zhou Wei
Fan Huiping
Zhang Chenjie
Abstract：Objective To analyze the relationship among serum low-density lipoprotein-cholesterol (LDL-C), Annexin A1 and severity of coronary artery stenosis in patients with coronary heart disease (CHD).Methods CHD patients (n=150) were divided, according to types, vessels of coronary artery lesions and Gensini scores, into different groups[acute myocardial infarction group (AMI group), unstable angina pectoris group (UAP group), stable angina pectoris group (SAP group), multi-vessel lesion group, 2-vessel lesion group and 1-vessel lesion group], and health controls (n=23) were chosen into control group.The levels of LDL-C and Annexin A1 were compared among all groups, and correlation among them and severity of coronary artery stenosis was analyzed.Results The levels of LDL-C and Annexin A1 were higher in AMI group than those in UAP group, and were higher in UAP group than those in SAP group.The levels of LDL-C and Annexin A1 were higher in SAP group than those in control group (P＜0.05).The levels of LDL-C and Annexin A1 were higher in multi-vessel lesion group than those in 2-vessel lesion group, and were higher in 2-vessel lesion group than those in 1-vessel lesion group (P＜0.05).The levels of LDL-C and Annexin A1 were higher in Gensini scores＞60 group than those in Gensini scores=30-60group, and were higher in Gensini scores=30-60 group than those in Gensini scores＜30 group (P＜0.05).Gensini scores were positively correlated to levels of LDL-C and Annexin A1(r=0.431, r=0.489, all P＜0.05).Conclusion The increases of LDL-C and Annexin A1 may be correlated to severity of coronary artery stenosis, which helps to disease condition reviewing and treatment.
Keywords：Low-density lipoprotein-cholesterolAnnexin A1Coronary artery stenosis
Publication Date：2018-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 1510-1512 )