Relationship among serum cystatin C, vascular endothelial function indexes and severity of coronary artery lesions in patients with coronary heart disease
Gong Baiqi
Zhang Lin
Wang Na
Li Qiang
Abstract：Objective To study the relationship among serum cystatin C (Cys C), vascular endothelial function indexes and severity of coronary artery lesions in patients with coronary heart disease (CHD). Methods The patients (n=200) with suspected CHD received coronary angiography (CAG) were chosen from Hospital of Beijing General Unit of Chinese People’s Armed Police from Feb. 2015 to Dec. 2017. The results of CAG showed that there were 152 CHD patients (observation group), and among them 55 with 1-vessel lesion, 57 with 2-vessel lesions and 40 with multi-vessel lesions. Other 48 non-CHD patients were chosen as control group. The observation group were divided, according to Gensini integrals, into high-integral subgroup (Gensini integral≥82, n=37), mid-integral subgroup (Gensini integral=32-81, n=64) and low-integral subgroup (Gensini integral≤31, n=51). The clinical data was compared, and correlation among CysC, reactive hyperemia index (RHI) and severity of coronary artery lesions were analyzed in all groups. Results The level of CysC was higher and RHI level was lower in observation group than those in control group (P<0.05). The level of CysC was significantly higher in patients with 2-vessel lesions and multi-vessel lesions than that in patients with 1-vessel lesion, and was higher in patients with multi-vessel lesions than that in patients with 2-vessel lesions. The level of RHI was significantly lower in patients with 2-vessel lesions and multi-vessel lesions than that in patients with 1-vessel lesion, and was lower in patients with multi-vessel lesions than that in patients with 2-vessel lesions (all P<0.05). The level of CysC was significantly higher in mid-integral subgroup and high-integral subgroup than that in low-integral subgroup, and was higher in high-integral subgroup than that in mid-integral subgroup. The level of RHI was significantly lower in mid-integral subgroup and high-integral subgroup than that in low-integral subgroup, and was lower in high-integral subgroup than that in mid-integral subgroup (all P<0.05). The results of Spearman analysis showed that numbers of lesion vessels and Gensini integrals were positively correlated to CysC (P<0.05) and negatively correlated to RHI (P<0.05). Conclusion The increase of serum CysC level and decrease of RHI level are closely correlated to numbers of lesion vessels and Gensini integrals in CHD patients, and CysC and RHI can be included in monitoring index system of CHD for serving diagnosis and treatment process more comprehensively.
Keywords：Coronary heart diseaseSerum cystatin CVascular endothelial function indexesSeverity of coronary artery lesionsRelationship
Publication Date：2018-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 1354-1357 )