Correlation between polymorphism of nitric oxide synthase gene T786-C and 4b/a and risk of coronary artery disease in Chinese population: a meta-analysis
Ma Linlu
Li Binghui
Guo Jiao
Zhao Mingjuan
Weng Hong
Liu Xincan
Abstract：Objective To discuss the correlation between polymorphism of nitric oxide synthase gene T786-Cand 4b/a and the risk of coronary artery disease (CAD) in Chinese population. Methods The databases of PubMed, EMbase, CNKI, Wan Fang Database and VIP were retrieved with computer for searching the case-control studies on the correlation between polymorphism of eNOS gene T786-C and 4b/a and risk of CAD in Chinese population up to Oct. 10, 2017. The literature was screened and data was extracted by 2 researchers independently according to inclusion and exclusion criteria, and after quality review on methodology the data was given a meta-analysis by using RevMan 5.3 software. Results There were totally 18 case-control studies including 4585 cases of CAD patients and 4555 healthy controls. The results of meta-analysis showed that polymorphism of eNOS gene T786-C might increase the risk of CAD in Chinese population (C vs. T: OR=1.67, 95%CI: 1.45~1.92; CC vs. TT: OR=2.35, 95%CI: 1.43~3.85; TC vs. TT:OR=1.68, 95%CI: 1.44~1.97; CC+TC vs. TT:OR=1.73, 95%CI:1.49~2.02; CC vs. TC+TT:OR=2.02, 95%CI: 1.23~3.30).The polymorphism of eNOS gene4b/a might increase the risk of CAD in Chinese population(a vs. b: OR=1.54, 95%CI: 1.34~1.77; aa vs. bb: OR=3.55, 95%CI: 2.15~5.86;ab vs. bb: OR=1.32, 95%CI: 1.12~1.55; aa+ab vs. bb: OR=1.48, 95%CI: 1.27~1.72; aa vs. ab+bb: OR=3.32, 95%CI: 2.01~5.49). Conclusion Based on current evidences, the polymorphism of eNOS geneT786-C and 4b/ais associated with increased risk of CAD in Chinese population.
Keywords：eNOSPolymorphismCoronary artery diseaseMeta-analysis
Publication Date：2018-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：6( 1299-1304 )