Value of brain natriuretic peptide and serum cystatin C in predicting heart failure and prognosis review in patients with arrhythmogenic right ventricular dysplasia
Wu Xianhao
Liu Baohong
Abstract：Objective To discuss the value of brain natriuretic peptide (BNP) and serum cystatin C (Cys C) in predicting heart failure and prognosis review in patients with arrhythmogenic right ventricular dysplasia (ARVD). Methods ARVD patients (n=81) were chosen from Tongren Hospital affiliated to School of Medicine of Shanghai Jiao Tong University from May 2013 to Jan. 2016. All patients were divided, according to heart function, into cardiac grade Ⅱ group (n=24), cardiac grade Ⅲ group (n=30) and cardiac grade Ⅳ group (n=27), and meanwhile other health persons (n=40) received physical examination were chosen into control group. The levels of BNP and Cys-c, and left ventricular ejection fraction (LVEF) and left ventricular end-diastolic inner diameter (LVEDd) were detected in all groups. Results The difference in BNP, Cys-c, LVEF and LVEDd was significant in different cardiac grade groups compared with control group (P<0.05). As the decrease of heart function, levels of BNP and Cys-c and LVEDd showed an ascending trend, and LVEF showed a descending trend, and difference was significant among different cardiac grade groups (P<0.05). The results of multi-factor Logistic regression analysis showed that BNP (OR=4.117) and Cys-c (OR=6.357) were independent predictive factors for heart failure in ARVD patients. The combined prediction of BNP and Cys-c for heart failure showed that AUC of ROC was 0.905 (95%CI:0.839-0.971), and sensitivity and specificity of which were higher than those of single prediction of BNP or Cys-c. After followed patients up for 18 months, and heart failure was taken as endpoint outcome for observing survival rate, the survival curve was significantly lower in BNP high-risk group (BNP≥731.43 ng/L) than that in BNP low-risk group (BNP<731.43 ng/L), and was significantly lower in Cys-c high-risk group (Cys-c≥2.14 mg/L) than that in Cys-c low-risk group (Cys-c<2.14 mg/L, P<0.05). Conclusion The combined prediction of BNP and Cys-c has value for predicting heart failure induced by ARVD, which can provide reference for clinical prognosis review.
Keywords：Arrhythmogenic right ventricular dysplasiaHeart failureBrain natriuretic peptideSerum cystatin C
Publication Date：2018-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 597-600 )