The influence of adiponectin to PGC-1α and Tfam in in patients with acute ST segment elevation myocardial infarction
Shen Xuhua
Qiu Hui
Liang Siwen
Hua Bing
Li Hongwei
Abstract：Objective To evaluate the influence of adiponectin (APN) with the mitochondrial transcription factor A (Tfam) and peroxisome proliferator - activated receptor gamma coactivator 1 alpha(PGC-1α). Methods 160 patients with acute ST segment elevation myocardial infarction undergoing primary PCI therapy within 12 hours were enrolled. The patients were randomly divided into two groups according to the median of the admission serum APN. Serum PGC-1α, Tfam, IL 6 and TNF - ɑ level were compared. Coronary angiography, myocardial perfusion and clinical prognosis were analyzed. Results The group of lower admission serum APN had higher percentage of smoking (4.0% vs. 52.7%, P=0.007). The serum creatinine level in myocardial infarction patients with high APN was lower (90.2±54.5mmol/L vs. 76.2±17.3mmol/L, P=0.022). In hospitalized patients with low level of APN, Gensini score was significantly higher (34.6±26.1 vs. 42.6±20.1, P<0.05). Hospitalized patients with low level of APN were considered the lower level of Tfam and PGC-1α (P<0.01), the higher levels of TNF alpha and IL - 6 (P<0.01). Conclusion These results demonstrated that the patients with severe coronary artery in acute ST segment elevation myocardial infarction were founded with the lower serum adiponectin level and the lower serum adiponectin in patients responded with higher inflammatory factor, lower Tfam and PGC-1α.
Keywords：AdiponectinTfamPGC-1αAcute ST-segment elevation myocardial infarction
Publication Date：2018-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 565-568 )