Relationship among levels of serum growth differentiation factor-15, cardiac troponin Ⅰ and short-term prognosis in patients with cardiopulmonary resuscitation
Li Jiang
Jia Baohui
Song Jiali
Abstract：Objective To discuss the relationship among levels of serum growth differentiation factor-15 (GDF-15), cardiac troponin I (cTnI) and short-term prognosis in patients with cardiopulmonary resuscitation (CPR). Methods The patients (n=104) with sudden cardiac arrest undergone success CRP were chosen from Emergency Department of People’s Hospital of Henan Province. The level of GDF-15 was detected by using ELISA and level of cTnI was detected by using automatic biochemical analyser immediately (0 h) and after CPR for 12 h and 24 h. The patients were divided, according to GDF-15 changes, into group A (n=34, without GDF-15 changes), group B (n=32, with gradually increased GDF-15) and group C (n=38, with increased and then decreased GDF-15). Results The levels of GDF-15 and cTnI increased significantly after CPR in all 3 groups (all P<0.05). The levels of GDF-15 and cTnI were significantly higher in group B and group C than those in group A after CPR for 12 h (all P<0.05), and had difference among 3 groups after CPR for 24 h (all P<0.05). The mortality and incidence of heart failure and non-lethal myocardial infarction were higher in group B than those in other 2 groups, and GDF-15 was positively correlated to cTnI (r=0.938, P=0.009). Conclusion The levels of GDF-15 and cTnI will increase in patients with sudden cardiac arrest after CPR, and GDF-15 and cTnI are positively correlated to each other. The levels of GDF-15 and cTnI can be taken to predict prognosis in patients after CPR.
Keywords：Cardiopulmonary resuscitationGrowth differentiation factor-15Cardiac troponin
Publication Date：2018-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 555-557 )