Cut-off value of atrial electrograms associated with termination of persistent atrial fibrillation by catheter ablation
Zheng Zhitao
Shi Liang
Tian Ying
Wang Yanjiang
He Shunan
Liu Xingpeng
Abstract：Objective To determine the cut-off value of atrial electrograms predictive of termination of Persistent atrial fibrillation (PsAF) during ablation. Methods Seventy-five consecutive patients undergoing catheter ablation of PsAF were studied from January 2105 to August 2015 in Beijing Chaoyang Hospital. Voltage and electrograms characteristics in terminated sites defined as termination of AF were compared with those in non-terminated sites. ROC curve was delineated to define the cut-off value of LVAE. Results Targeted ablation electrograms in terminated sites characterized by: 1) uninterrupted continuous electrical activity; 2) interrupted continuous electrical activity; 3) complex fractionated activity. Mean voltage in targeted electrograms were 0.16 ± 0.08 mV, 0.23 ± 0.10 mV and 0.20 ± 0.16 mV, respectively (P＞0.05). Mean voltage of final targeted electrograms in terminated sites was lower than that in non-terminated sites (0.19 ± 0.10 mV vs. 0.33 ± 0.15 mV, P＜0.01). Cut-off value of atrial electrograms in terminated sites was 0.33 mV with high specificity and moderate sensibility (91.7% and 55.6%, respectively). Area under curve of ROC curve was 0.79 (P＜0.01). Conclusion Catheter ablation at sites displaying a lower voltage electrograms is associated with termination of PsAF. The finding of cut-off value of Low-voltage atrial electrograms is important when choosing appropriate electrograms to ablate in PsAF.
Keywords：Persistent atrial fibrillationRadiofrequency ablationLow-voltageAtrial electrograms
Publication Date：2018-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 544-547 )