Correlation between polymorphisms of 607C/A and 137G/C, promoters of interleukin-18, and coronary artery disease: a Meta-analysis
Zhao Runmin
Song Bing
Zhu Kaimeng
Zhao Pengying
Abstract：Objective To investigate the correlation between polymorphisms of 607C/A and 137G/C, promoters of interleukin-18 (IL-18), and coronary artery disease (CHD). Methods The databases of PubMed, EMbase, Web of Science, ScienceDirect, CNKI, VIP and WanFang Data were retrieved with computer for searching and screening relative case-control studies. Meanwhile similar studies and references in retrieved results were consulted. The retrieving duration was from establishment time of each database to Feb. 26, 2017. The studies were screened and data extracted by 2 reviewers independently, and then given a Meta-analysis and other relevant statistical analysis by using StataSE 12.0 software. Results In Asian population, risk of CHD was lower in population with allele A of IL-18 607C/A polymorphism (OR=0.628, 95%CI: 0.533~0.740, P<0.001), and this correlation was not observed in Caucasian population (OR=0.950, 95%CI: 0.803~1.124, P=0.548). The analysis by dominant gene model showed that the population with AA/CA genotypes of IL-18 607C/A polymorphism was negatively correlated to risk of CHD (OR=0.431, 95%CI: 0.326~0.570, P<0.001), and this correlation was not observed in Caucasian population. The polymorphism of IL-18 137G/C had no statistical correlation with risk of CHD in Asian population (OR=0.843, 95%CI: 0.577~1.231) and Caucasian population (OR=1.071, 95%CI:0.807~1.421). Conclusion Allele A of IL-18 607C/A polymorphism has a preventive effect on Asian population from SHD, and 137G/C polymorphism is not correlated to CHD risk. More studies with larger sample and multi-center are needed to further verify the conclusion.
Keywords：Promoters of interleukin-18PolymorphismCoronary artery diseaseMeta-analysis
Publication Date：2018-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：6( 538-543 )