Predictive value of PLR and NLR to no-reflow during PCI and postoperative major adverse cardiovascular and cerebrovascular events in patients with acute myocardial infarction
Song Hongxing
Zhang Jie
Ma Longfei
Guo Heli
Han Xinyu
Zhang Ying
Lu Zhaohui
He Ran
Yuan Yiqiang
Abstract：Objective To investigate the predictive value of platelet to lymphocyte ratio (PLR) and neutrophil to lymphocyte ratio (NLR) to no-reflow during PCI and postoperative major adverse cardiovascular and cerebrovascular events (MACCE) in patients with acute myocardial infarction (AMI). Methods The clinical materials of AMI patients (n=121) received PCI were retrospectively analyzed. The best cutoff value of PLR was determined according to receiver operating characteristic curve (ROC), according to which the patients were divided into high risk group and low risk group. The clinical materials, no-reflow during PCI and incidence of MACCE in hospitalization and follow-up period were compared between 2 groups. Results The results of ROC showed that when PLR≥168.83, its specificity was 84.67% and sensitivity was 85.54% in predicting no-reflow during PCI in AMI patients. The patients were divided, according to cutoff value of PLR, into high risk group (n=32, PLR≥68.83) and low risk group (n=89, PLR<168.83), and general data had no significant difference between 2 groups (P>0.05). LVEF was significantly lower and peak value of CK-MB was significantly higher in high risk group than those in low risk group after PCI. The incidence of MACCE was significantly higher in high risk group than that in low risk group in hospitalization period (P<0.05). The patients were followed up for 8 months to 6 y, the total incidence of MACCE was significantly higher in high risk group than that in low risk group (P<0.05). The analysis of Kaplan-Meier survival curve showed that non-all-cause mortality survival rate and non-MACCE survival rate were significantly higher in low risk group than those in high risk group. The analysis of COX risk model showed that high PLR and high NLR were independent risk factors for predicting no-reflow during PCI and postoperative MACCE in AMI patients. Conclusion PLR and NLR are indexes with higher clinical value for predicting no-reflow during PCI and postoperative MACCE in AMI patients.
Keywords：Acute myocardial infarctionPlatelet to lymphocyte ratioNeutrophil to lymphocyte ratioNo-reflow during PCIPostoperative major adverse cardiovascular and cerebrovascular events
Publication Date：2018-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 484-487,492 )