Applicative effect of ticagrelor in postoperative antiplatelet treatment in patients with acute myocardial infarction and clopidogrel resistance after PCI
Chang Guodong
Chen Yingwei
Abstract：Objective To analyze the applicative effect of ticagrelor in postoperative antiplatelet treatment in patients with acute myocardial infarction (AMI) and clopidogrel resistance after PCI. Methods AMI patients (n=80, male 43 and female 37) undergone PCI were chosen from the First People's Hospital of Shangqiu City from Feb. 2015 to Aug. 2016. All of them suffered from clopidogrel resistance. All patients were randomly divided into control group and test group (each n=40), and given aspirin before and after PCI. The test group was additionally given ticagrelor before PCI and routine maintenance dose of ticagrelor after PCI for 7 d. The levels of platelet aggregation rate (PAG), serum creatinine (SCr) and aspertate aminotransferase (AST) were detected and adverse reactions were recorded before and after PCI. The patients were followed up for 6 months to record major adverse cardiovascular and cerebrovascular events (MACCE). Results The level of PAG was significantly lower in test group than that in control group (all P<0.05) after PCI for 2 h, 1 d and 7 d. The level of SCr was higher in 2 group after PCI than before, and was higher in test group than that in control group (all P<0.05). The incidence of MACCE was 25.0% (10/40) in control group and 5.0% (2/40) in test group (P<0.05). The incidence of adverse reactions was 5.0% in control group and 12.5% in test group (P<0.05). The adverse reactions were short, tolerable and terminable after discontinuing treatment. Conclusion Ticagrelor can significantly inhibit PAG, incidence of MACCE is lower and adverse reactions are tolerable in postoperative antiplatelet treatment in AMI patients with clopidogrel resistance after PCI.
Keywords：Acute myocardial infarctionPercutaneous coronary interventionTicagrelorClopidogrel resistance
Publication Date：2018-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 466-468 )