Relationship between serum 25(OH)D3and ambulatory blood pressure monitoring and morning peak blood pressure in patients with hypertension

Liu Yamei; Xu Jiang; Li Xiaoyun

doi:10.3969/j.issn.1674-4055.2018.04.13

Abstract：Objective To explore the relationship between serum 25(OH)D3and ambulatory blood pressure monitoring (ABPM) and morning blood pressure surge (MBPS) in patients with hypertension. Methods 97 patients with essential hypertension were recruited in Orthopedics hospital of Qinhuangdao from Jan 2016 to Jun 2016, then they were divided into normal group (n=33) and deficient group (n=64) according to serum 25(OH)D3level. 24 h blood pressure was detected by ABPM, and the 24 h systolic blood pressure (24h SBP), 24h diastolic blood pressure (24h DBP), dSBP, dDBP, nSBP, nDBP, nocturnal blood pressure drop rate recorded and it has been determined whether the patient has MBPS. Venous blood was collected to detect fasting plasma glucose (FBG), total cholesterol (TC), triglyceride (TG), low density lipoprotein cholesterol (LDL-C), HDL-C and 25(OH)D3. Results The 24h SBP, 24h DBP, dSBP, nDBP, dSBP, nDBP and MBPS incidence rate in deficient group were significantly higher than those in normal group, while the nocturnal blood pressure drop rate were lower than those in normal group. The 24h SBP, 24h DBP, dSBP, nDBP, dSBP, nDBP and MBPS incidence rate were in negative correlation with serum 25(OH)D3level, while the nocturnal blood pressure drop rate was in positive correlation with serum 25(OH)D3level. Conclusion The deficiency of serum 25(OH)D3 level were closely related to the increase of blood pressure and the incidence of morning peak blood pressure. It was proved that 25(OH)D3participated in the circadian rhythm regulation of blood pressure and provided a new idea for the treatment of morning peak blood pressure.