Influence of recombinant human brain natriuretic peptide on heart function in elderly patients with decompensated heart failure
Chang Lianqing
Zhao Xiangfang
Liu Naiqin
Lyu Chunlei
Wang Wenbo
Wang Xianhua
Kong Yuan
Han Shengxiang
Wang Yu
Abstract：Objective To investigate the influence of recombinant human brain natriuretic peptide (rhBNP) on heart function in elderly patients with decompensated heart failure (DHF). Methods Elderly DHF patients (n=82) were chosen from the Department of Geriatrics of Chinese PLA 464 Hospital from Mar. 2013 to May 2017, and divided, according to order of hospitalization, into observation group and control group (each n=41). All patients in 2 groups were treated with routine anti-heart failure therapy, and control group was additionally given nitroglycerin (NTG) and observation group, additionally, rhBNP. The heart function, level of N-terminal pro-brain natriuretic peptide (NT-proBNP) and clinical efficacy were observed and compared in 2 groups. Results The comparison in left ventricular ejection fraction (LVEF), left ventricular end-diastolic inner diameter (LVEDd) and NT-proBNP showed that difference had no statistical significance (P>0.05). LVEF, LVEDd and NT-proBNP were significantly improved in observation group after treatment, which was more significant in observation group than that in control group (P<0.05). The total clinical efficacy was 92.11% in observation group and 73.17% in control group (P<0.05). Conclusion RhBNP has significant clinical efficacy, and can improve heart function and relieve ventricular remodeling in elderly DHF patients.
Keywords：Recombinant human brain natriuretic peptideAgednessDecompensated heart failureHeart functionN-terminal pro-brain natriuretic peptide
Publication Date：2018-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 345-347 )