Expression and prognosis of MMP-2 in patients with ST segment elevation myocardial infarction
Tuo Tian
Guo Junlin
Abstract：Objective To study the plasma matrix metalloproteinase-2 (MMP-2) in ST segment elevation myocardial infarction (STEMI) patients to observe the expression of registry of acute coronary events (GRACE) changes in plasma MMP-2 score, effect of MMP-2 on prevention of adverse cardiovascular events. Methods From September 2013 to September 2015, 110STEMI patients (STEMI group) and 100 healthy persons (control group) were selected. Plasma MMP-2 index were measured by ELISA assay. The patient's GRACE score was calculated. General clinical data and MACE events within 6 months after discharge were recorded. Results The level of MMP-2 in STEMI patients was significantly higher than that in the control group [(183.47±46.51) ng/ml vs. (66.26 ±26.73) ng/ml], the difference was statistically significant (P<0.05). In 6 months after discharge from STEMI, 34 patients developed MACE, and MMP-2 and GRACE scores in MACE group were significantly higher than those in non-MACE group (all P<0.05). The area under the curve of MACE predicted by GRACE score and MMP-2 level in 6 months after STEMI were 0.711 (95%CI: 0.565~0.856, P=0.013) and 0.737 (95%CI: 0.601~0.873, P=0.005). Conclusion MMP-2 has some predictive value for the recent occurrence of MACE in STEMI patients.
Keywords：Matrix metalloproteinase -2Coronary artery diseaseRisk assessment
Publication Date：2018-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 297-299,303 )