Meta-analysis of the association between SNP83 polymorphism of PDE4D gene and ischemic stroke in Chinese population
Hu Yi
Zhang Ting
Chen Wenjing
Zhang Xiachun
Ye Lu
Li Li
Abstract：Objective To systematically evaluated the correlation between SNP83 polymorphism in phosphodiesterase 4D (PDE4D) gene and ischemic stroke (IS) in Chinese Han population by meta-analysis. Methods The following databases such as PubMed, EMbase, CBM, CNKI, WanFang Data and VIP were searched to collect case-control studies about the relationship between PDE4D gene SNP83 polymorphism and IS in Chinese population. The retrieval time was from their establishment to January, 2017. Two researchers independently screened the literature according to the inclusion and exclusion criteria and extracted the data. The quality of the literature was assessed according to the NOS. Then the meta-analysis was performed by Stata 12.0 software. Results A total of 14 case-control studies which are 9 in Chinese and 5 in English involving 4119 IS patients and 4286 controls. The results of meta-analysis showed that, for Chinese Han population, no significant association was observed in all five genetic models (C vs. T: OR=1.13, 95%CI: 0.95~1.33, P=0.17; CC vs. TT: OR=1.12, 95%CI: 0.80~1.57, P=0.52; CT vs. TT:OR=1.22, 95%CI: 0.91~1.63, P=0.23; CC vs. CT+TT: OR=1.10, 95%CI: 0.81~1.49, P=0.56; CC+CT vs. TT: OR=1.14, 95%CI: 0.93~1.41, P=0.21). Conclusion Current evidence showed that PDE4D gene SNP83 polymorphism may not be significantly associated with an increased risk of IS in Chinese Han population.
Keywords：PDED4Gene polymorphismChinese populationIschemic strokeSystematic reviewMeta-analysis
Publication Date：2018-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 279-282 )