A meta-analysis of 15 case-control studies evaluating the relationship between the angiotensinogen gene T174M polymorphism and essential hypertension in Han Chinese
Gu Wei
Lin Yun
Wang Su
Ceng Yutong
Zhang Jingmei
Li Zhizhong
Abstract：Objective To investigate the relationship between the angiotensinogen (AGT) gene T174M polymorphism and essential hypertension (EH) in the Han Chinese population. Methods To find out all the case-control studies that met the inclusion criteria, we conducted a computer retrieval of Medline, Embase, CNKI, Wanfang and VIP databases prior to August 2017. The association between the T174M polymorphism and hypertension risk was examined through quantitative analysis by RevMan 5.0 software. The analysis included the calculation of the pooled odds ratio (OR) as well as 95% confidence interval (CI). The evaluation of the between-study heterogeneity and the performance of sensitivity analysis. The Stata 10.0 software was used to assess the publication bias. Results According to the inclusion criteria, 15 eligible articles involving 3730 cases and 3273 controls were included in the present study. Then, we found no statistical association between the T174M polymorphism and EH risk in all subjects or in the subgroups by area. However, a significant association was observed between the T174M polymorphism and a hypertensive group (systolic blood pressure ≥ 160 mmHg and/or diastolic blood pressure ≥ 95 mmHg) in the dominant genetic model (MM+MT vs. TT: OR=1.82, 95%CI: 1.20~2.76, P=0.005). Conclusion There are not enough evidence for the genetic association of the AGT gene T174M polymorphism with hypertension risk in the Han Chinese population.
Keywords：AngiotensinogenHypertensionPolymorphismHanChineseMeta-analysis
Publication Date：2018-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：6( 269-274 )