Relationship of red blood cell distribution width with early kidney injury and cardiac remodeling in patients with hypertension
Ge Peibing
Geng Jin
Zhang Dongying
Zhang Gang
Gu Yang
Abstract：Objective To investigate the relationship of red blood cell distribution width (RDW) with early kidney injury and cardiac remodeling in patients with hypertension. Methods A total of 107 cases with coronary artery stenosis <50% diagnosed by coronary angiography or coronary CT angiography were selected in Huai'an First People's Hospital, Nanjing Medical University from Aug 2016 to Aug 2017. According to hypertension or not, 107 cases were divided into hypertension group(n=76) and control group(n=31). The difference and correlation of RDW and estimated glomerular filtration rate(eGFR) were compared between the two groups. The left ventricular end-diastolic diameter (LVEDD), interventricular septal thickness (IVST), left ventricular posterior wall thickness (LVPWT), ejection fraction (EF) and fractional shortening (FS) of all the objects were measured by echocardiography, as well as the left ventricular mass index (LVMI), and the correlation with RDW. Receiver operator characteristic (ROC) curve was used to find the optimal cutoff point for predicting the occurrence of early target organ damages of hypertension in these participants. Results The RDW levels in hypertension group were significantly higher than that in control group (P<0.05), while eGFR levels of hypertension group were significantly lower than control group (P<0.05). The LVEDD, IVST and LVMI levels were dramatically higher in hypertension group than in control groups (P<0.05). We found that RDW had a significantly correlation with eGFR (r=-0.236, P=0.140) and LVMI (r=0.468, P<0.001). ROC curve of RDW predicting early kidney injury and cardiac remodeling showed that the area under curve of RDW were 0.623 and 0.720(P<0.05), respectively. Multivariate logistic regression analysis showed that RDW was independently associated with hypertension (P<0.05). Conclusion RDW in patients with hypertension is correlated with early kidney injury and cardiac remodeling. Thus, RDW can be used as a predictor to evaluate the early target organ damages in hypertension patients.
Keywords：HypertensionRed blood cell distribution widthEstimated glomerular filtration rateLeft ventricular mass index
Publication Date：2018-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 233-236 )