Correlation between endothelin-1 and in-stent restenosis after percutaneous coronary intervention in patients with coronary heart disease
Tang Xin
Li Fenghua
Qin Lubing
Abstract：Objective To analyze the relationship between level of endothelin-1 (ET-1) and in-stent restenosis after percutaneous coronary intervention (PCI) in patients with coronary heart disease (CHD). Methods CHD patients (n=174, male 125, female 49 and aged from 42 to 71) were chosen from the General Hospital of Liaohe Oilfield from Jan. 2013 to Dec. 2015. All of them were divided, according to follow-up results, into stenosis group (n=36) and control group (n=138). The data was collected including sex, age, blood fat, complications, history of myocardial infarction, and stent numbers and diameter from all patients. The level of ET-1 was detected after PCI, and the patients were followed up for 1 y to record onset status of in-stent restenosis. Results The percentages of patients complicated by hypertension or diabetes, length of stent, and levels of aspertate aminotransferase (AST) and ET-1 were all higher, and stent diameter was lower in stenosis group than those in control group (all P<0.05). The results of multi-factor Logistic regression analysis showed that complicated diabetes (OR=2.451, 95%CI:1.123~5.364), stent diameter (OR=0.625, 95%CI: 0.415~0.994) and ET-1 (OR=1.528, 95%CI: 1.208~2.824) were independent influence factors of in-stent restenosis after PCI in CHD patients. When ET-1 level was 96.5 pg/mL, its sensitivity was 80.6% and specificity was 76.8% in diagnosis of in-stent restenosis after PCI within 1 y in CHD patients. Conclusion The higher level of ET-1 is correlated to in-stent restenosis in CHD patients after PCI, and detection of ET-1 level is help to review the risk of in-stent restenosis.
Keywords：Endothelin-1Coronary heart diseasePercutaneous coronary interventionIn-stent restenosis
Publication Date：2018-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 227-229 )