Relationship among anxiety-depression,inflammatory response and vascular endothelial function in patients with coronary heart disease
Zhang Xiaolei
Zhao Yongfeng
Ren Yanchun
Wu Zhihong
Wang Yunying
Hu Xitian
Abstract：Objective To discuss the relationship among anxiety-depression, inflammatory response and vascular endothelial function in patients with coronary heart disease (CHD). Methods CHD patients (n=99, male 51, female 48, aged from 50 to 78 and average age=62.11±3.49) were chosen from the Department of Cardiovascular Medicine, First Hospital of Shijiazhuang City from Feb. 2014 to Apr. 2017. The patients with anxiety-depression were included into study group (n=41) and those without anxiety-depression, into control group (n=58). The level of anxiety-depression was determined by using hospital anxiety and depression scale (HADS), including total HADS (HADS-t), HADS for anxiety (HADS-a) and HADS for depression (HADS-d). The levels of serum myeloperoxidas (MPO), lipoxin A4 (LXA4), C-reactive protein (CRP), interleukin-8 (IL-8), tumor necrosis factor-α (TNF-α) and soluble vascular cell adhesion molecules-1 (sVCAM-1) were detected. The endothelium-dependent brachial artery flow-mediated dilation (FMD) and non-endothelium-dependent nitroglycerin-mediated dilatation (NMD) were determined. Results The scores of HADS-t, HADS-a and HADS-d were all higher in study group than those in control group (all P<0.05). Compared with control group, levels of MPO, LXA4, CRP, IL-8 and TNF-α increased significantly in study group (all P<0.05). The level of sVCAM-1 was significantly higher, and levels of FMD and NMD were significantly lower in study group than those in control group (all P<0.05). The levels of serum MPO, LXA4, CRP, IL-8, TNF-α and sVCAM-1 were positively correlated to scores of HADS-t, HADS-a and HADS-d (all P<0.05). The levels of FMD and NMD were negatively correlated to scores of HADS-t, HADS-a and HADS-d (all P<0.05). Conclusion Inflammatory response and injury of vascular endothelial function are more serious in CHD patient complicated by anxiety-depression. The levels of inflammatory factors are positively correlated to anxiety-depression severity, and vascular endothelial function is negatively correlated to anxiety-depression severity.
Keywords：Adverse emotionsCoronary heart diseaseInflammatory responseMechanism of action
Publication Date：2018-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 199-202 )