Relationship between stability of carotid plaques and levels of LP-PLA2, A-FABP and hs-CRP in postmenopausal woman patients with essential hypertension
Qu Li
Liu Xia
Yan Xiaoyan
Wei Yongtao
Abstract：Objective To discuss the correlation between stability of carotid plaques and levels of lipoprotein associated phospholipase A2 (LP-PLA2), adipocyte fatty acid-binding protein (A-FABP) and high-sensitivity C-reactive protein (hs-CRP) in postmenopausal woman patients with essential hypertension (EH). Methods The postmenopausal woman patients with EH (n=125, aged from 55 to 81 and average age=65.98±7.47) were chosen from the Eighth People's Hospital of Qingdao City from Aug. 2014 to Nov. 2015. All of them were given color Doppler ultrasound examination for diagnosing carotid plaque formation, and according to plaque features, they were divided into stable plaque group (n=96) and unstable plaque group (n=29). The general clinical materials, laboratory results (including LP-PLA2 and A-FABP), and carotid ultrasound results were collected from all patients. Results The level of hs-CRP was significantly higher in unstable plaque group than that in stable plaque group (P<0.05). The results of multi-factor Logistic regression analysis showed that hs-CRP (OR=2.162, 95%CI: 1.189~4.032) and A-FABP (OR=1.017, 95%CI: 1.001~1.038) were influence factors on stability of carotid plaques in postmenopausal woman patients with EH. Conclusion The levels of hs-CRP and A-FABP is correlated to, and level of LP-PLA2 is not correlated to stability of carotid plaques in postmenopausal woman patients with EH.
Keywords：Postmenopausal womenEssential hypertensionCarotid plaquesLipoprotein associated phospholipase A2Adipocyte fatty acid-binding proteinHigh-sensitivity C-reactive protein
Publication Date：2018-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 173-175,178 )