Expressions of angiogenin-2 and vascular endothelial growth factor in patients with idiopathic atrial fibrillation
Wu Haoyu
Gao Tianjiao
Han Wenqi
Wang Congxia
Zhong Ni'er
Chen Haichao
Abstract：Objective To analyze the expressions and significance of angiogenin-2 (Ang-2) and vascular endothelial growth factor (VEGF) in patients with idiopathic atrial fibrillation (IAF). Methods IAF patients (n=78) were chosen from the People's Hospital of Shaanxi Province from Jan. 2016 to Apr. 2017, and divided into paroxysmal atrial fibrillation group (PAF group, n=36) and sustained atrial fibrillation group (SAF group, n=42). Meanwhile, patients with paroxysmal supraventricular tachycardia (PSVT) without AF history were chosen into control group (n=20). The levels of high-sensitivity C-reactive protein (hs-CRP), Ang-2 and VEGF were detected. Results The levels of VEGF, Ang-2 and hs-CRP showed an ascending trend in control group, PAF group and SAF group (all P<0.05 ). The results of correlation analysis showed that Ang-2 was positively correlated to VEGF (r=0.679, P<0.001), and hs-CRP was positively correlated to VEGF (r=0.705, P<0.001). Conclusion The levels of Ang-2 and VEGF increase significantly in IAF patients, and the increase is more significant in SAF patients. Ang-2 and VEGF have positive correlation in IAF patients.
Keywords：Idiopathic atrial fibrillationEndothelial dysfunctionHigh-sensitivity C-reactive proteinAngiogenin-2Vascular endothelial growth factor
Publication Date：2018-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 167-169 )