The value and clinical significance of IgG and IgM expression in the diagnosis of unstable angina pectoris

Liu Lu; Yang Shizhi; Liu Wenting

doi:10.3969/j.issn.1674-4055.2018.01.27

Abstract：Objective To investigate the value of IgG and IgM in the diagnosis of unstable angina pectoris and its correlation with the levels of TNF-α, CRP, tPA and PAI-1. Methods The patients with unstable angina pectoris treated from February 2016 to April 2017 were selected as the subjects, and the healthy adults who underwent physical examination were selected as the control group. To observe the expression of two groups of IgG and IgM, the difference between the two groups of serum TNF-α, CRP, tPA, PAI-1 and heart function index, correlation analysis in patients with unstable angina IgG, the expression of IgM and TNF-α, CRP, tPA, alpha PAI-1 and cardiac function index. Results The positive rate of IgG in the unstable angina pectoris group was higher than that in the control group, and there is no difference of the positive rate of IgM between the two groups. The serum levels of TNF-α, CRP and PAI-1 in the patients with unstable angina pectoris were higher than those in the control group, and there was no significant difference in the levels of tPA between the two groups. The levels of LAD, RAD and BNP in the patients with unstable angina pectoris were higher than those in the control group, and the level of LVEF was lower than that of the control group. Unstable angina in patients with IgG positive expression rate of TNF-α and CRP, PAI-1, alpha, LAD, RAD and BNP correlated inversely related to LVEF levels, while the positive expression rate of IgM and TNF-α, CRP, tPA, alpha PAI-1 and heart function index has no significant correlation. Conclusion The positive expression of IgG in patients with unstable angina pectoris is higher, and is closely related to the levels of TNF-α, CRP and PAI-1.