Curative effect of anti-platelet therapy at different time in patients with coronary heart disease
Cao Hongtao
Sun Qingpo
Di Tao
Gao Jiangyan
Hu Qing
Abstract：Objective To compare the curative effect of anti-platelet therapy at different time in patients with coronary heart disease (CHD) after implanted drug eluting stent (DES). Methods CHD patients implanted domestic targeted eluting stents (n=360, male 186 and female 174) were chosen from Hebei Provincial Chest Hospital from May 2014 to May 2017. The patients were divided, according to different treatment time of dual anti-platelet therapy, into test group (>12 months) and control group (≤12 months, each n=180). The general conditions were recorded, and major adverse cardiovascular events (MACE) and bleeding events were recorded after followed up for 18 months in 2 groups. Results The difference in age, ratio of sex and percentages of patients complicated by hypertension, hyperlipidemia, diabetes or coronary artery lesions had no statistical significance between 2 groups (all P>0.05). The difference in incidence of revascularization, heart failure, non-lethal myocardial infarction and cardiac death had no statistical significance between 2 groups (all P>0.05). The incidence of angina pectoris was significantly lower in test group than that in control group (3.33% vs. 8.89%, P<0.05). The difference in incidence of severe bleeding events and mild bleeding events had no statistical significance between 2 groups (all P>0.05). Conclusion After implanted DES, the curative effect of dual anti-platelet therapy with treatment time for more than 12 months is better a little than that with treatment time for equal or less than 12 months in CHD patients. This conclusion needs further verification through study with enlarged sample size.
Keywords：ClopidogrelAspirinTargeted eluting stentTreatment time
Publication Date：2018-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 37-39 )