Risk of coronary heart disease (CHD) and polymorphism of gene-519A/G in matrix metalloproteinase-1 (MMP-1): a Meta-analysis
Guo Jiao
Qu Jianxin
Abstract：Objective To discuss the relationship between polymorphism of gene-519A/G in matrix metalloproteinase-1 (MMP-1) and risk of coronary heart disease (CHD) by applying Meta-analysis. Methods The databases of PubMed, EMbase, CBM, CNKI, Wanfang Data and VIP Database were retrieved with computer for searching relevant case-control studies up to July, 2016. The literature screening, data extracting and quality reviewing were carried out independently by 2 authors. All data was given a Meta-analysis by using Stata 12.0 software. Results There were totally 6 case-control studies included involved 2027 patients and 1654 controls. The results of Meta-analysis showed that polymorphism of gene-519A/G in MMP-1 was related to the decrease of CHD risk in allelic genetic model (G vs. A: OR=0.68, 95%CI: 0.49~0.94, P=0.02), heterozygote model (AG vs. AA:OR=0.62, 95%CI: 0.40~0.95, P=0.03), dominant model (GG+AG vs. AA: OR=0.61, 95%CI: 0.40~0.94, P=0.03), and recessive model (GG vs. AA+AG: OR=0.76, 95%CI: 0.59~0.97, P=0.03), while had no statistical significance in homozygote model (GG vs. AA: OR=0.59, 95%CI: 0.35~1.00, P=0.05). The results of subgroup analysis showed that the decrease of CHD risk was more significant in Asian population. Conclusion The current evidence suggests that polymorphism of gene-519 A/G in MMP-1 may be related to the decrease of CHD risk, especially in Asian population. Due to limited quantity of included studies, the conclusion needs further studies to be confirmed.
Keywords：Coronary heart diseaseMatrix metalloproteinase-1Meta-analysis
Publication Date：2018-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 19-22 )