Changes and significance of levels of serum MR-pro-adrenomedullin, pentraxins-3, brain natriuretic peptide and ST-2 in patients with heart failure
Wang Jianfeng
Wu Gaoqiang
Chen Chunhong
Abstract：Objective To study the changes and significance of levels of serum MR-pro-adrenomedullin (MR-proADM), pentraxins-3 (PTX-3), brain natriuretic peptide (BNP) and ST-2 in patients with heart failure (HF). Methods HF patients (n=90, male 52 and female 38) were chosen from the People's Hospital of Tongchuan City of Shaanxi Province from Sept. 2015 to June 2017. The patients were divided, according to NYHA grading, into NYHAⅡ group (n=28), NYHA Ⅲ group (n=32) and NYHA Ⅳ group (n=30), and health controls (n=40) were chosen into control group at the same time. The levels of PTX-3, ST-2 and MR-proADM were detected by using enzyme-linked immunosorbent assay (ELISA), and BNP level was detected by using electro-chemiluminescence immunoassay (ECLIA) in all groups before and after treatment.Results The levels of MR-proADM, PTX-3, BNP and ST-2 all showed an ascending trend in all groups, and the comparison among all groups had statistical significance (allP<0.05). Compared with before treatment, levels of MR-proADM, PTX-3, BNP and ST-2 all decreased significantly in all groups after treatment (allP<0.05).Conclusion The levels of MR-proADM, PTX-3, BNP and ST-2 all increased significantly in HF patients, and will be higher along with the decrease of heart function. The detection of levels of MR-proADM, PTX-3, BNP and ST-2 can be one of methods for diagnosing HF severity.
Keywords：Heart failureMR-pro-adrenomedullinPentraxins-3Brain natriuretic peptideST-2
Publication Date：2017-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 1504-1506 )