Curative effect of tanshinoneⅡA in patients with congestive heart failure

Song Xiurong; Wang Yong

doi:10.3969/j.issn.1674-4055.2017.12.21

Abstract：Objective To observe the curative effect of tanshinone ⅡA in patients with congestive heart failure (CHF).Methods CHF patients (n=60, male 21, female 39, aged from 41 to 57 and average age=49.53±4.33) were chosen from the Department of Cardiology of Central Hospital of Baotou City from July 2015 to July 2016. The patients were randomly divided into observation group and control group (eachn=30), and at the same time 60 health controls were chosen into normal group. The control group was given routine treatment and observation group was additionally given tanshinone ⅡA continuously for 15 d. The levels of nitric oxide (NO), N-terminal pro-brain natriuretic peptide (NT-proBNP), 6-keto prostaglandin F1a (6-keto-PGF1a) and vascular Willebrand factor (vWF) were detected in normal group at time of grouping, day of hospitalization and 15 d after treatment. The level of left ventricular ejection fraction (LVEF) was detected by using color Doppler ultrasonic diagnostic apparatus. The clinical efficacy was reviewed after treatment.Results The levels of NO and NT-proBNP decreased and LVEF increased in observation group and control group after treatment (allP<0.05). The levels of NO and NT-proBNP decreased and LVEF increased in observation group compared with control group after treatment (allP<0.05). The difference in levels of NO and LVEF had no statistical significance between normal group and observation group after treatment (allP>0.05). The levels of 6-keto-PGF1a increased and vWF decreased in observation group and control group after treatment, and these changes were more significant in observation group after treatment (allP<0.05). The difference in levels of 6-keto-PGF1a and vWF had no statistical significance between normal group and observation group after treatment (allP>0.05). The total effective rate was 93.33％ in observation group and 66.67％ in control group (P<0.05).Conclusion Tanshinone ⅡA added into routine therapy can significantly improve heart function and vascular endothelial function with reliable curative effect in patients with CHF.