Interaction between LRP5 gene and LRP6 gene and correlation between this interaction and prognosis in patients with coronary heart disease after PCI
Fang Xiang
Li Changling
Sun Yong
Abstract：Objective To study the interaction between low-density lipoprotein receptor-related protein 5 (LRP5) gene and LRP6 gene and correlation between this interaction and prognosis in patients with coronary heart disease (CHD) after PCI.Methods CHD patients undergone PCI (n=600, PCI group) and patients with negative results of coronary angiography (n=600, control group) were chosen from June 2011 to June 2014. The levels of blood sugar, blood fat, serum creatinine (SCr), homocysteine (Hcy) and high-sensitivity C-reactive protein (hs-CRP) were detected after collecting fasting vein blood. There were 9 single nucleotide polymorphisms (SNP) of LRP6 and 2 SNP of LRP5 related to CHD chosen from HapMap database. All patients were given relevant genotype analysis, and followed up for 1 y to record the incidence of major adverse cardiovascular events (MACE).Results LRP6 had 3 genotypes (SNP6-1, SNP6-2, SNP6-7) and they were correlated to incidence of MACE after PCI. SNP6 and SNP7 were greatly correlated to incidence of MACE (OR=0.62, 95％CI: 0.54～0.87,P=0.005). SNP of LRP5 was not significantly correlated to incidence of MACE after PCI. The interaction between LRP5 gene and LRP6 gene had relevance with incidence of MACE after PCI (OR=0.43, 95％CI: 0.34～0.65,P=0.02).Conclusion LRP5 gene and LRP6 gene and interaction between them are correlated to incidence of MACE in CHD patients after PCI.
Keywords：Low-density lipoprotein receptor-related proteinCoronary heart diseasePercutaneous coronary interventionCardiovascular events
Publication Date：2017-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 1471-1473 )