Influence of rosuvastatin on inflammatory factors in patients with acute coronary syndrome complicated by arrhythmia
Du Jianqing
Zhang Daifu
Abstract：Objective To discuss the effect of rosuvastatin on inflammatory factors and apoptosis response in patients with acute coronary syndrome (ACS) complicated by arrhythmia.Methods The patients with simple ACS (n=50, ACS group) and patients with ACS complicated by arrhythmia (n=50, ACS+arrhythmia group) were chosen from the People's Hospital of Pudong New District in Shanghai City from May 2011 to May 2015, and treated orally with rosuvastatin (10 mg) every night before bed. The indexes of blood fat, aspertate aminotransferase (AST), alanine aminotransferase (ALT), creatine kinase-MB isoenzyme (CK-MB), plasma von Willebrand factor (vWF, ％), and inflammatory factors including fatty acid synthase (FAS), interleukin-1β (IL-1β), high-sensitivity C-reactive protein (hs-CRP), tumor necrosis factor-α (TNF-α) and interleukin-18 (IL-18) were compared in 2 groups before and after treatment. The correlation between Lown grading of premature ventricular contraction (PVC) and inflammatory factors was analyzed in ACS+arrhythmia group before and after treatment.Results The difference in indexes of blood fat (except of LDL-C), AST, ALT, CK-MB and plasma vWF had statistical significance between 2 groups before and after treatment (P<0.05). The levels of all inflammatory factors were significantly higher in ACS+arrhythmia group than those in ACS group before treatment (P<0.05), and difference in levels of inflammatory factors had statistical significance in 2 groups before and after treatment (P<0.05). The levels of inflammatory factors increased along with Lown grading of PVC increased progressively in ACS+arrhythmia group before and after treatment.Conclusion ACS complicated by arrhythmia is positively correlated to inflammatory factors, which indicates that inflammatory factors are important cause of ACS complicated by arrhythmia. Rosuvastatin has the effects of anti-inflammation and anti-apoptosis with significant efficacy in treatment of ACS complicated by arrhythmia, and it is worthy of clinic popularization and application.
Keywords：RosuvastatinAcute coronary syndrome complicated by arrhythmiaInflammatory factorsApoptosis responseLown grading of premature ventricular contraction
Publication Date：2017-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 1458-1460,1463 )