Application of prostaglandin-E1 (PG-E1) combined with hydration in PCI and its influence on serum creatinine and inflammatory reactions

Fan Zhiwei; Ding Huixia; Zhang Qijie

doi:10.3969/j.issn.1674-4055.2017.11.25

Abstract：Objective To study the application of prostaglandin-E1 (PG-E1) combined with hydration in percutaneous coronary intervention (PCI) and its influence on serum creatinine (SCr) and inflammatory reactions. Methods The patients with coronary heart disease (CHD, n=68) undergone PCI were chosen from Jiangbei Area of Zhongda Hospital of Southeast University from Aug. 2015 to June 2017, and divided, according to treatment status, into observation group and control group (each n=34). The control group (male=19 and female 15) were given hydration therapy, and observation group (male=18 and female 16) was given PG-E1 combined with hydration therapy. Results The levels of brachial artery flow-mediated dilation (FMD) and nitric oxide (NO) were significantly higher in observation group than those in control group after treatment (P<0.05). The levels of endothelin (ET) and high-sensitivity C-reactive protein (hs-CRP) were significantly lower in observation group than those in control group after treatment (P<0.05). The incidence of angina pectoris, heart failure, major adverse cardiovascular events (MACE) and in-stent restenosis were all significantly lower in observation group than those in control group after treatment (P<0.05). The incidence of acute myocardial infarction (AMI) and sudden cardiac death had no significant difference between 2 groups (P>0.05). The value of SCr decreased significantly, and value of endogenous creatinine clearance rate (Ccr) increased significantly in observation group compared with control group after PCI (P<0.05). Conclusion The therapy of PG-E1 combined with hydration can reduce inflammatory reactions, SCr level and incidence of MACE in CHD patients undergone PCI.