Meta-analysis of the association between periodontal disease and myocardial infarction
Chen Shaohua
Wang Chaoyang
Zi Hao
Zheng Zhongli
Li Binghui
Zeng Xiantao
Cheng Guanchang
Abstract：Objective To evaluate the association between periodontal disease and myocardial infarction. Methods The PubMed, CNKI and WanFang Databases were retrieved for collecting the relevant literature up to January 31, 2017 (February 7, 2017 update search). Meta-analysis was performed using R 3.3.3 software after data extraction and quality assessment of included studies. Results Finally, 32 observational studies were included: 5 cohort studies, 21 case-controlled studies, and 6 cross-sectional studies. All of them were high quality. Result of adjusted meta-analysis showed that periodontal disease increased risk of myocardial infarction 2.09 times (OR=2.09, 95%CI:1.75~2.48, P<0.01), and result of sensitivity analysis showed good stability. The funnel graph showed a significant publication bias. Conclusion Periodontal disease is likely to be a risk factor for myocardial infarction.
Keywords：Periodontal diseasePeriodontitisMyocardial infarctionRisk factorsMeta-analysis
Publication Date：2017-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：6( 1294-1299 )