Influence of Danhong Injection in patients with chronic heart failure
Wang Fei
Xu Jingjing
Zhu Shijun
Chen Shaobo
Zhu Miao
Abstract：Objective To discuss the curative effect and influence of Danhong Injection in patients with chronic heart failure (CHF).Methods CHF patients (n=84, male 47 and female 37) were chosen from the Department of Cardiovasology of Affiliated Hospital of Logistics University of Chinese People's Armed Police from Apr. 2014 to Dec. 2015, and then divided, according to random digital table, into control group and study group (eachn=42). The control group was treated with routing drugs according to patients' conditions, and study group, with Danhong Injection additionally. The indexes of endothelin-1 (ET-1), calcitonin gene-related peptide (CGRP), nitric oxide (NO), tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6), interleukin-1β (IL-1β), nuclear factor kappa (NF-κB), fibrinogen (FIB) and D-dimer (D-D) were detected before and after treatment for 1 week. The indexes of left ventricular end-systolic diameter (LVESD), left ventricular end-diastolic inner diameter (LVEDD), left ventricular diameter (LVD) and left ventricular ejection fraction (LVEF) were detected. The curative effect was reviewed. Results The content of ET-1 decreased, and content of NO and CGRP increased in 2 groups after treatment (allP<0.05). Compared with control group, content of ET-1 decreased, and content of NO and CGRP increased in study group after treatment (allP<0.05). The content of TNF-α, IL-6, IL-1β and NF-κB decreased in 2 groups after treatment (allP<0.05). Compared with control group, content of TNF-α, IL-6, IL-1βand NF-κB decreased in study group after treatment (allP<0.05). The content of plasma FIB and D-D decreased in 2 groups, and decreased more significantly in study group after treatment (allP<0.05). The levels of LVESD, LVEDD and LVD decreased, and LVEF increased in 2 groups after treatment (allP<0.05). Compared with control group, the levels of LVESD, LVEDD and LVD decreased, and LVEF increased in study group after treatment (all P<0.05). The clinical effective rate was 90.48% in study group and 71.43% in control group (P<0.05).Conclusion In treatment of CHF, routine drugs combined with Danhong Injection can improve vascular endothelial function andfibrinolytic system, inhibit inflammatory reaction and promote heart function.
Keywords：Danhong InjectionChronic heart failureHeart functionFibrinogenTumor necrosis factor-αInterleukin-6
Publication Date：2017-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 1229-1232 )