Influence of clopidogrel resistance on prognosis and risk factor analysis in elderly patients with coronary heart disease complicated by diabetes after percutaneous coronary intervention
Huang Zhenglin
Gao Yue
Zhang Haibo
Ren Ping
Long Yi
Abstract：Objective To investigate the influence of clopidogrel resistance on prognosis and risk factor analysis in elderly patients with coronary heart disease (CHD) complicated by diabetes after percutaneous coronary intervention (PCI).Methods The patients (aged>60,n=248) were chosen from the Department of Cardiology of People's Hospital of Ya'an City from May 2012 to May 2016, and then divided, according to inhibition rate of thrombelastogram (TEG), into study group (n=116, male 68, female 48 and average age=69.3±8.4) and control group (n=132, male 101, female 31 and average age=68.7±7.6). The clinical materials, glycolipid metabolism, inflammation indexes and incidence of major adverse cardiovascular events (MACE) were compared between 2 groups.Results The level of high-density lipoprotein-cholesterol (HDL-C) was significantly lower, and levels of fasting plasma glucose (FPG), glycated serum protein (GSP) and high sensitivity C-reactive protein (hs-CRP) were significantly higher in study group than those in control group (P<0.05). The incidence of MACE was significantly higher in study group than that in control group (P<0.05). The multi-factor Logistic analysis showed that FPG, hs-CRP and HDL-C were independent risk factors influencing on prognosis.Conclusion Clopidogrel resistance has some influence on prognosis, promote MACE incidence after PCI, and it is the independent risk factors influencing on prognosis in elderly patients with CHD complicated by diabetes.
Keywords：Coronary heart diseaseDiabetesClopidogrel resistancePercutaneous coronary intervention
Publication Date：2017-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 1226-1228 )