Analysis of the relationship between no-reflow phenomenon and coronary artery lesion and endothelium inflammation in AMI patients

Liu Fang; Wang Liping; Xie Tongjie

doi:10.3969/j.issn.1674-4055.2017.10.21

Abstract：Objective To investigate the relationship between no-reflow phenomenon with coronary artery lesion and endothelial inflammation in patients with acute myocardial infarction (AMI).Methods 105 patients with AMI in Xinhua Hospital of Dalian University from April 2013 to January 2017 were enrolled in this study. 38 patients with no-reflow were treated as observation group. 67 patients with no-reflow were randomly divided into control group. Both two groups underwent coronary angiography and percutaneous coronary intervention (PCI). According to the results of angiography, the observation group was divided into single-vessel disease group with 16 cases, double-vessel disease group with 10 cases and three-vessel disease group (GMP2) with 12 cases. Serum circulating blood endothelial cells (EMPs) and soluble intercellular adhesion molecule-1 (sICAM-1) were observed and recorded. The no-reflow influencing factors were analyzed.Results The mean level of EMP was (2453.17 ±252.61)/ul and sICAM-1 was (515.84±96.72) ng/ml in the observation group, which was significantly higher than those in the control group (P<0.05). With the severity of coronary artery lesions, the Gensini scores, BNP and EMPs levels increased significantly, and there were statistical significant differences between the two groups (P<0.05). There was no significant correlation between EMPs level and age, incidence time, hypertension, diabetes mellitus, hyperlipidemia and smoking history (P>0.05). There was a significant correlation between Gensini score, BNP and Hs-CRP levels.Conclusion EMPs and sICAM-1 are the markers of endothelial injury and endothelial inflammation in patients with AMI after PCI treatment, no reflow and endothelial inflammation is closely related to the detection of EMPs and sICAM-1 can reflect the severity of coronary artery lesions to a certain extent, is conducive to the prognosis.