Influence of body mass index on prognosis in patients with heart failure complicated by hyponatremia

Wang Jianjun; Dong Haishan; Wen Lirong

doi:10.3969/j.issn.1674-4055.2017.10.20

Abstract：Objective To analyze the influence of body mass index (BMI) on the prognosis in patients with heart failure (HF) complicated by hyponatremia.Methods The patients (n=79, male 20 and female 59) were continuously chosen from the Beijing Rehabilitation Hospital and Beijing Mentougou District Hospital from Jan. 2014 to Dec. 2016. All patients were divided into BMI<18.5 kg/m2 group (n=38) and BMI≥18.5 kg/m2 group (n=41). The medical materials were collected from the patients and analyzed. All patients were followed up for one year for recording patients' survival situation.Results The condition of disease was more serious, blood pressure and left ventricular ejection fraction (LVEF) were lower, and NYHA grading and brain natriuretic peptide (BNP) were higher in BMI<18.5 kg/m2 group than those in BMI≥18.5 kg/m2 group. There were 7 patients died during hospitalization, and hospitalization-case fatality rate was 8.9% (7/79). The all-cause mortality was 21.5% (17/79) and mortality due to aggravated HF was 16.5% (13/79) during 1-year follow-up period. The results of Kaplan-Meier survival analysis showed that accumulated hospitalization-case fatality rate, accumulated all-cause mortality of 1-year follow-up period and accumulated HF mortality of 1-year follow-up period were significantly higher in BMI<18.5 kg/m2 group than those in BMI≥18.5kg/m2 group (allP<0.01). After correcting the levels of BNP, LVEF, left ventricular end-diastolic inner diameter (LVEDD), systolic blood pressure (SBP) and diastolic blood pressure (DBP), low level of BMI was the important influence factor of death in patients with HF complicated by hyponatremia (HR=4.221, 95%CI: 1.011~17.626).Conclusion The lower BMI is an influence factor of prognosis in patients with HF complicated by hyponatremia.