Curative effect of combined glucocorticoid in patients with connective tissue diseases complicated by refractory heart failure
Meng Tao
Cao Hua
Gu Yang
Shi Yafei
Abstract：Objective To discuss the curative effect of routine anti-heart failure therapy combining glucocorticoid (GC) in patients with connective tissue diseases complicated by refractory heart failure (RHF). Methods The clinical materials from the patients (n=18, male 2, female 16, aged from 48 to 67 and average age=51 ±11) in the First People's Hospital of Huai'an City of Jiangsu Province were retrospectively analyzed from Jan. 2009 to Dec. 2015. All patients were given routine anti-heart failure therapy combining GC. The cardiac output (CO), cardiac output index (CI), left ventricular ejection fraction (LVEF), N-terminal pro-brain natriuretic peptide (NT-proBNP), 6-minute walk distance (6MWD) and heart rate (HR) were compared before and after treatment. Results NT-proBNP [(1588.0±45.6) pg/mLvs. (455.7±22.3) pg/mL], 6MWT [(98.9±25.4) mvs. (404.6±85.3) m], CO [(3.78±0.24) L/minvs. (4.50±0.71) L/min], CI [(1.82±0.38) L·min-1·m-2vs. (2.73±0.34) L·min-1 ·m-2], LVEF [(37±6) %vs. (56±14) %] and HR [(108±12) time/minvs. (74±21) time/min] were improved after treatment compared with before treatment (allP<0.05).Conclusion The curative effect of anti-heart failure therapy combining GC is significant in patients with connective tissue diseases complicated by RHF. As the sample size is small, the further large-sample study is needed to confirm the conclusion.
Keywords：GlucocorticoidConnective tissue diseasesRefractory heart failure
Publication Date：2017-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：2( 1211-1212 )