Effects of long-term Rosuvastatin calcium used on ascending aorta elasticity in patients with Coronary atherosclerotic heart disease
Zhao Yunfeng
Liu kun
Yin Delu
Abstract：Objective To study the effects of using long-term rosuvastatin calcium used on ascending aorta elasticity in patients with coronary atherosclerotic heart disease (CHD).Methods 156 consecutive patients in hospital from 2010 April to 2012 December diagnosed with CHD were divided into rosuvastatin (n=80, rosuvastatin 10 mg, qn) and simvastatin (n=76, simvastatin 20mg, qn) treatment group by random in a 18-month follow-up. Using Doppler tissue imaging assessment, ascending aorta elasticity was evauated by measuring aortic stiffness index, aortic distensibility and S velocity of anterior wall of ascending aorta before treatment and after treatment 6,12 and 18 months, respectively. Serum low density lipoprotein cholesterol (LDL-C), LDL-C was tested. The data described above were statistically analyzed.Results Although no significant difference was observed after 6-month rosuvastatin treatment (72 cases), the aortic stiffness index exhibited significant decrease (P=0.012) until treatment for 18 months compared with the baseline. Both aortic distensibility and S velocity of anterior wall of ascending aorta increased significantly (P<0.05) after 18-month rosuvastatin treatment. After 18 months treatment with simvastatin(70 cases), the aortic stiffness index, the aortic distensibility and S velocity of anterior wall of ascending aorta in patients appeared no significant difference (P>0.05) compared with the baseline group. Conclusion Long-term rosuvastatin calcium treatment in patients with CHD could not only decrease serum LDL-C level, but also be effective in the treatment of the ascending aorta elasticity.
Keywords：Rosuvastatin calciumSimvastatinCoronary atherosclerotic heart diseaseAscending aortaElasticityEfficacy
Publication Date：2017-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 1199-1201 )