Danhong Injection combined with Naoxintong Capsules intervening vascular endothelial function in elderly patients with early lesion of diabetic nephropathy: reviewed with EndoPAT2000
Wang Xiaobing
Wei Wanlin
Zhang Wei
Wu Yuntao
Xia Changquan
Yao Lu
Liu Hui
Zhao Buchang
Abstract：Objective To observe the amelioration of vascular endothelial function by applying noninvasive vascular endothelial diagnosis system (EndoPAT2000) in elderly patients with early lesion of diabetic nephropathy (DN) after intervention of Danhong Injection combined with Naoxintong Capsules.Methods The patients (age>75, n=92) were chosen from the Fourth Department of Geriatrics,Chinese PLA Army General Hospital from Jan. 2014 to Jan. 2017,and then divided randomly into observation group and control group (n=46) on the base of controlling blood sugar level. The control group was treated continuously with perindopril for 6 months,and observation group was treated with Danhong Injection, Naoxintong Capsules and perindopril for 2 weeks and then with Naoxintong Capsules and perindopril for 6 months. The changes of 24-h quantification of urine protein (UP) and vascular endothelial function were compared in 2 groups after treatment.Results The total effective rate was 82.61% in observation group, which was significantly higher than that in control group (56.52%). The Endo-PAT index (RHI) was significantly improved in 2 groups (P<0.05),and improvement of vascular endothelial function was significantly superior in observation group to that in control group.Conclusion The indexes of vascular endothelial function are significantly lower than normal value in patients with early lesion of DN,and Danhong Injection combined with Naoxintong Capsules can improve the therapeutic efficacy and vascular endothelial function. EndoPAT2000 can be taken as a practical indicator to review the treatment of early lesion of DN.
Keywords：Diabetic nephropathyDanhong InjectionNaoxintong CapsulesIndex of vascular endothelial function
Publication Date：2017-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 1169-1171 )