Pharmaceutical economics research of Shen Xian Sheng Mai oral liquid in the treatment of slow arrhythmia based on Meta analysis
Wang Wenwen
Lu Ying
Zhang Yu
Wang Siyue
Liu Chang
Zhu Wentao
Abstract：Objective To evaluate the efficacy, safety and economy of Shen Xian Sheng Mai oral liquid in the treatment of slow arrhythmia.Methods Literature databases (2000.1~2016.10) including PubMed, CNKI and so on were searched. Random control trials of Shen Xian Sheng Mai oral liquid published at home and abroad were collected. Meta-analysis was conducted using RevMan 5.3 software and economic evaluation was used cost-effectiveness analysis.Results 8 literatures were included, invovling 666 patients. Meta analysis results showed that Shen Xian Sheng Mai oral liquid group is better than that of Xin Bao Wan group in the treatment of slow arrhythmia effect (OR=4.71, 95%CI: 2.96~7.50,P<0.001), the fastest heart rate (SMD=10.51, 95%CI: 6.37~14.64, P<0.001), the slowest heart rate (SMD=6.54, 95%CI: 4.82~8.26,P<0.001), the mean heart rate (SMD=6.00, 95%CI: 3.72~8.28,P<0.001) and the 24h total heart rate (P<0.05). There is no significant difference of adverse reactions between Shen Xian Sheng Mai oral liquid group and Xin Bao Wan group (OR=0.49, 95%CI: 0.13~1.85, P=0.29). Pharmacoeconomic analysis results showed that Shen Xian Sheng Mai oral liquid group in the treatment of slow arrhythmia, periods of daily cost were increased 1.05~1.06 yuan. The incremental cost effectiveness of each disease is less than the per capital GDP, which shows that the cost of the increase in effectiveness is worth. Conclusion Shen Xian Sheng Mai oral liquid in the treatment of slow arrhythmia has better clinical efficacy and cost-effectiveness, more high quality and large sample randomized controlled trials are needed.
Keywords：Shen Xian Sheng Mai oral liquidMeta-analysisPharmaceutical economics analysisClinical effects
Publication Date：2017-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 1165-1168,1174 )