Comparison of clinical effect of ticagrelor and clopidogrel in emergency PCI of STEMI patients
Li Yong
Peng Wei
Chen Wenrong
Xu Neiwei
Abstract：Objective To compare effects of ticagrelor and clopidogrel in percutaneous coronary intervention (PCI) of acute ST-segment elevation myocardial infarction (STEMI) patients. Methods From January 2014 to January 2016, 87 patients received emergency PCI were enrolled, including ticagrelor group (n=43) and clopidogrel group (n=44). TIMI blood flow before and after PCI was compared. The platelet inhibition rate was measured at 24 h and 1 month after operation. The incidence of major adverse cardiovascular events (MACE) and bleeding events was recorded within 12 months. Results TIMI blood flow was significantly improved in both groups after PCI. In ticagrelor group, 83.72% were TIMI grade 3, 11.63% were TIMI grade 2, 4.65% were TIMI grade 1. In clopidogrel group, 63.64% were TIMI grade 3, 25% were TIMI grade 2, 11.36% were TIMI grade 1. The platelet inhibition rate in ticagrelor group was (84.2±11.4)% at 24 h after operation and (75.8±9.7)% at 1 month postoperatively, which was higher than that in clopidogrel group (69.1±12.7)% (62.5±8.6)%, the difference was statistically significant (P<0.05). The incidence of severe heart failure in the ticagrelor group was lower than that in the clopidogrel group, the difference was statistically significant (P<0.05). There was no significant difference in the incidence of other MACE and bleeding events. Conclusion In patients with STEMI before and after the emergency PCI, ticagrelor has better platelet inhibition than clopidogrel, has better postoperative blood perfusion effect, and was safer.
Keywords：ST segment elevation myocardial infarctionPercutaneous coronary interventionGrilloClopidogrel
Publication Date：2017-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 1124-1126 )