Level changes of C-reactive protein and procalcitonin and their predictive values to successful drug cardioversion in patients with atrial fibrillation
Liu Shuang
Cui Weizheng
Han Shasha
Wang Xin
Yang Chao
Li Xiao
Ren Liang
Li Aijun
Wei Xiaocui
Liu Jiayan
Abstract：Objective To analyze the changes of C-reactive protein (CRP) and procalcitonin (PCT) and their predictive values to successful drug cardioversion in patients with atrial fibrillation (AF). Methods AF patients (n=94, male 59, female 35 and average age=61.79±0.79) were chosen from the Department of Emergency of Central Hospital of Handan City from Jan. 2013 to Jan. 2017. Meanwhile the patients with normal sinus rhythm (NSR) but without AF history (n=28) were chosen into control group. All AF patients were divided into paroxysmal AF group (n=63) and persistent AF group (n=31). The levels of CRP and PCT were detected in all subjects. The predictive values of CRP and PCT to successful drug cardioversion were reviewed by using receiver operating characteristic curve (ROC) in all groups. Results Compared with control group, the levels of CRP and PCT increased in paroxysmal AF group and persistent AF group (all P<0.05). The levels of CRP and PCT increased in persistent AF group compared with paroxysmal AF group (all P<0.05). The level of CRP was positively correlated to level of PCT (r=0.465, P<0.01) in AF patients. The rate of drug cardioversion to NSR was 77.78% in paroxysmal AF group and 51.61% in persistent AF group. The area under curve (AUC) of ROC in diagnosing successful drug cardioversion by PCT from AF, paroxysmal AF and persistent AF was, respectively, 0.78, 0.79 and 0.73, and AUC of ROC in diagnosing successful drug cardioversion by CRP from AF, paroxysmal AF and persistent AF was, respectively, 0.72、0.71、0.62. Conclusion The levels of CRP and PCT increase in AF patients, which may be valuable to prediction of successful drug cardioversion from AF.
Keywords：C-reactive proteinProcalcitoninAtrial fibrillationDrug cardioversion
Publication Date：2017-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 1089-1091 )