Effectiveness and safety of injection of verapamil and tirofiban with thrombus aspiration catheter in STEMI patients during emergent PCI
Chen Shaoyuan
Wu Zhenyuan
Liu Rongzhi
Wang Zhibing
Wang Huizhi
Xie Peiyi
Abstract：Objective To investigate the curative effect and safety of injection of verapamil and tirofiban with thrombus aspiration catheter in patients with acute ST-segment elevation myocardial infarction (STEMI) during emergency emergent percutaneous coronary intervention (PCI). Methods STEMI patients (n=128, male 96 and female 32) were chosen from the Shenzhen Nanshan Hospital affiliated to Guangdong Medical University from Jan. 2015 to Apr. 2016, and then they were divided into routine group (n=64) and test group (n=64) according to random digital table. The routine group was given verapamil and tirofiban through ostium of coronary artery by using guiding catheter, and test group was given the same dose of verapamil and tirofiban by using super-selective thrombus aspiration catheter after reached distal criminal lesion. The postoperative blood flow, corrected TIMI frame count (CTFC), ST-segment resolution, creatine kinase-MB isoenzyme (CK-MB) and left ventricular ejection fraction (LVEF) were observed, and major adverse cardiovascular events (MACE) and adverse reactions were recorded during hospitalization. Results Compared with routine group, CTFC [(27.47±5.58) vs. (23.43±4.57)] and CK-MB [(97.63±15.32) U/L vs. (85.44±14.23) U/L] decreased, ST-segment resolution proportion (65.6% vs. 81.2%) and LVEF [(42.78±7.80)% vs. (47.53±7.50)%] increased in test group (all P<0.05). The difference in incidence of adverse reactions and MACE had no statistical significance between 2 groups (all P>0.05). Conclusion The injection of verapamil and tirofiban by using thrombus aspiration catheter at distal criminal lesion of coronary artery can effectively improve myocardial perfusion and has higher safety in STEMI patients during emergent PCI.
Keywords：Acute ST-segment elevation myocardial infarctionThrombus aspiration catheterPercutaneous coronary interventionVerapamilTirofiban
Publication Date：2017-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 1083-1085,1088 )